Structure-cooperativity relationship in ileal bile acid binding proteins
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چکیده
Background: Ileal bile acid binding proteins display different degrees of binding cooperativity. Results: The structure of a low cooperative protein complexed with bile salts was determined. The protein was mutated to enhance its cooperativity. Conclusion: The cooperative binding requires few latch residues that stabilize an H-bond network. Significance: Knowledge of the determinants of cooperativity in protein carriers is key to understand bile acid trafficking.
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تاریخ انتشار 2011